Mechanisms of Action

Potential Mechanisms of  Action  of commonly used treatments for ITP 
Immunologic Effect Anti-D IVIg Corticosteroids
Reticuloendothelial Blockade + + +/-
Altered FcR
binding 		+/- + +
Dec. Platelet antibody binding - +/- +
T-cell
suppression 		- + +
Dec. Immunoglobulin Synthesis +/- + +
Dec. Cytokine production - + +

Note: +/- denotes possible but not proven mode of action

This table is compiled from numerous publications of Treatment of ITP and represents the author's conclusions of mechanisms of actions of various therapies

Reference: Ware R, Zimmerman S: Anti-D: Mechanism of Action: Seminars in Hematology, Vol. 35 No1, Supply 1(January), 1998 pp 14-22