Disease Concept of (Auto) Immune Thrombocytopenic Purpura (ITP)

ITP is an autoimmune disorder wherein antibodies are directed against target antigens on glycoprotein IIb/IIIa or glycoprotein Ib/IX complex of the patient's platelets.

These auto antibodies result in impaired platelet numbers and cause platelets to be removed by Fc receptors in the reticuloendothelial system, primarily macrophages in the spleen.

ITP is a disease of increased platelet destruction. Platelet production is normal or remains near normal.

ITP at a glance

	Disease that is autoimmune in origin, mediated by antibodies in some way
	Pathophysiology currently not fully understood
	Disease causing low platelet count
	Disease which results in bruising and bleeding